Existential Proof for Dr. Toshiaki NISHIGAKI in the World
(Updated on July 26, 2018)


Toshiaki NISHIGAKI, Ph. D.

Name; Toshiaki Nishigaki, Pharamcist, Ph.D.
Nationality; Japanese, Male
Date of Birth; June 1^st, 1948
Age; 70
Marital Status; Married, two children
Home Address; 1286-18, Azusagawa Yamato, Matsumoto, Nagano, 390-1701 JAPAN
Permanent Address: 421 Osaki, Sekinomiya, Yabu, Hyogo, JAPAN
Home TEL; +81-263-78-4632
Office TEL; +81-263-26-7588
Mobile Phone; +81-90-2723-8626
E-mail: 
mk-info@thisismk.co.jp
buahmerah@po.mcci.or.jp
drnoni@noni-ken.jp
thisismk2@gmail.com

Education:
March 1972: B.S. Faculty of Pharmacy, Nagasaki University, Nagasaki, Japan
                        Registered Pharmacist in 1975
1975~1988: Research Student, Department of Pathology, Faculty of Medicine, Shinshu University , Nagano, Japan
1989: Degree of Ph.D, (Medicine), Shinshu University
2000~Present: Special Researcher, Faculty of Medicine, Shinshu University, Nagano, Japan

Employment:
April 1972: Kissei Pharmaceutical Industry, Co., Ltd.
                     Toxicological researchers for 7 new registered ethical drugs
1989~1993: Food and Drug Safety Research Foundation, Ministry of Health and Welfare, Hatano, Kanagawa, Japan
1989-1993: Expert of Japan International Cooperation Agent (JICA) at the Bureau of Food and Drug (BFAD), Department of Health, Philippines
1993~1998: INA Research Center, Ina, Nagano, Japan
1994~1996 INA Research Philippines (INARP), Philippines .
                     President,  Establishment of Prime Research Center
1998~2002: JICA Research Member for Official Development Aids (ODA)of Japan, 
                       to Indonesia, Guatemala, China, Mauritania
2000: Incorporated M&K Laboratories, Inc., Japan
            President
2001-Present: Chairman of Tokyo Noni Research Center
2008~Present: Consultant of M&K Laboratories, Inc.

Study Field:
Toxicology, Pathology, Radio-Autography, 
Allergy, Electron-Microscopy, Nutrition, Biochemistry

Study/Business Career
Indonesian Indigenous Herbal Plants
     1. Mengkudu (Noni) – Juice, Puree, Powder, Leaf, Root, Concentration
     2. Buah Merah
     3. Coconut oil (EVCO)
     4. Jahe Merah
     5. Jahe emprit
     6. Temlawak (C. xanthorrhiza) 
     7. Kaempeferia rotunda
     8. Soarsop
     9. Ashitaba
    10. Javanese long pepper
    11. Sirih
~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~

On-Going Study in R/D
     12. Bawang merah
     13. Mungbean
     14. Essential oils
     15. Cincau hitam
     16. Serang semut
      17. Cassava 
      18. Cecang
      19. Kumis kucing 
      20. Mimba (Neem) 

The Others:
2007: MOU with CABI in R/D of Indonesian medicinal plants
            MTA with CABI for Buah Merah

MOU b/w CABI


 MTA & MOU b/w CABI

at CABI, Bogor 

2009: Organic certification in Noni juice, powder, dried leaves with PTMI
2014: Patent acquisition in Buah Merah Oil Production with CABI, Ministry of Indistry
2001~Present: 
     Developed Products;
     Noni juice (EP and PP), Freeze-dried hard/soft capsules
     Noni tea, Noni tea bag, Noni soap, Noni capsule for dogs
     EVCO, EVCO sticks, Noni fruit mixed powder, Jahe Merah powder, 
     Buah Merah500, Buah Merah300VE, Buah Merah500VE
2017: Award of Indonesia Innovation Day 2017 (IID 2017) for Buah Merah 500VE
2018: Award of Indonesia Innovation Day 2018 (IID 2018) for Organic Noni Juice

Memories and Help of Papua Province Government

IID 2017 Award in the Netherland

Collaborating Institute:
1. Nagasaki University
2. Nagasaki International University
3. Shinshu University
4. Toyama University
5. Mukogawa Women’s University
6. Sanyo-Onoda City University
7. Tokyo Noni Research Center
8. Center for Agro-Based Industry (CABI)
9. Binus University
10. University of Papua

Related Web Site:
http://www.thisismk.co.jp
https://buahmerah.mixh.jp/
https://www.blogger.com/blogger.g?blogID=1327803476262000319#allposts/src=sidebar
https://tkyn.mixh.jp/
http://beigedo.blogspot.com/

Bibliography:

1. Maya Kudo, Hisae Yoshitomi, Toshiaki Nishigaki, Ming Gao. The Effects of Morinda citrifolia (Noni) Fruit Juice on the Prevention of Stroke by Promoting Production of Nitric Oxide through the Brain of the Spontaneously Hypertensive Stroke Prone (SHRSP) Rats. J Nutritional Therapeutics. 2018;7: 000-000
2. Dyah Anita Kustiarini, Toshiaki Nishigaki, Hiroyuki Kanno, Hide To. Effects of Morinda citrifolia (Noni) on Rheumatoid Arthritis in SKG mice. 2018; Under publication
3. Mayuko Hatai, Hisae Yoshitomi, Toshiaki Nishigaki, and Ming Gao^. Inhibitory effect of Buah Merah oil on melanogenesis via degradation of tyrosinase..J Agro-Based Industry. 2018; Under publication.
4. Mitsuhiro Wada, Kaori Fujimoto, Toshiaki Nishigaki, Erna Febriyante, Rie Ikeda and Kenichiro Nakashima. DETERMINAT10N OF α- ANDβ-CRYPTOXANTHINS, AND α- ANDβ-CAROTENS IN BUAH MERAH OIL BY HPLC-UV DETECTION. J Agro-Based Industry. 2013; 30(1):1-8
5. Takanori Maeda, Haruka Miyakita, Manami Goto, Akemi lto, Hendra Wijaya, Inggrid S. Surono, Toshiaki Nishigaki. MUTAGENICITY STUDY OF PANDANUS CONOIDEUS OIL. J Agro-Based Industry. 2013;30(2):21-30
6. Mathelda K. Rorweng, Toshiaki Nishigaki. BUAH MERAH AND PAPUAN PEOPLE. J Agro-Based Industry. 2013;30(1):37-48
7. Toshiaki NISHIGAK11, Fitriya N.A. DEWI, Hendra WIJAYA and Hidekazu SHIGElATSUl. ACUTE AND SUBACUTE TOXICITY STUDIES OF PANDANUS CONOIDEUS (BUAH MERAH) EXTRACT OIL IN SPRAGUE DAWLEY RATS. J Agro-Based Industry. 2011;28(1):11-20
8. Toshiaki NISIIIGAK1, Kunitaka HIROSE, Ingrid S. Surono and Hidekazu SIIIGE IATSU. ANTITUM0R EFFECTS OF PANDANUS CONOIDEUS IN INVITRO AND IN VIVO STUDIES. J Agro-Based Industry. 2011;28(2):1-7
9. Mitsuhiro Wada, Megumi Kira, Hirotsugu Kido, Rie Ikeda, 
   Naotaka Kuroda,Toshiaki Nishigaki, Kenichiro Nakashima. Semi‐micro flow injection analysis method for evaluation of quenching effect of health foods or food additive antioxidants on peroxynitrite. Luminescence. 2011; 26 (3), 191-195.
10. Rie Ikeda, Mitsuhiro Wada, Toshiaki Nishigaki, Kenichiro Nakashima. Quantification of cumarin derivatives in noni (Morinda citrifolia) and their 
    contribution of quenching effect on reactive oxygen species. Food Chemistry.2009;113:1169-1172
11. Tetsuo Ohashi, Akihiko Watanabe, Toshiaki Nishigaki and Hiroshi Azuma. Electron Microscopic Studies on the Inhibition of Degranulation of Rat Mast Cells by a Novel Anti-Allergic Agent, PTPC. Jpn J Pharmacol. 1994; 66:7-16.
12. Nishigaki T¹, Momose Y, Nagata T. Electron microscopic radioautographic study of the localization of an anti-allergic agent, Tranilast, in rat mast cells. Cell Mol Biol. 1990;36(1):65-71.
13. Nishigaki T¹, Momose Y, Nagata T. Localization of the anti-allergic agent tranilast in the urinary bladder of rats as demonstrated by light microscopic radioautography. 1990;40(3):272-5.
14. , Horie S, Yamada J, Isaji M, Nishigaki T, Naito J, Suga T. Species differences in the effects of bezafibrate, a hypolipidemic agent, on hepatic peroxisome-associated enzymes. Biochem Pharmacol. 1989;38(2):367-71.
15. Nishigaki T¹. Mast cell degranulation and its inhibition by an anti-allergic agent tranilast. An electron microscopic study. Virchows Arch B Cell Pathol Incl Mol Pathol. 1988;55(5):311-22.
16. Momose Y, Nishigaki T, et al. Species difference of peroxisome proliferation in hepatocytes by the hypolipidemic agent, bezafibrate. Quantitative microscopy comparison. Clinical Report. 1988;22(13):4379-4388 (Article in Japanese)
17. Nishigaki T¹. Mast cell degranulation and its inhibition by an anti-allergic agent tranilast. An electron microscopic study. Virchows Arch B Cell Pathol Incl Mol Pathol. 1988;55(5):311-22.
18. Isaji M, Nishigaki T, et al. Toxicity Study of Bezafibrate (1). Clinical Report. 1988;22(13):4293-4300 (Article in Japanese)
19. Momose Y, Nishigaki et al. Toxicity Study of Bezafibrate (2). Clinical Report. 1988; 22(13):4301-4336 (Article in Japanese)
20. Harold Chesterman, Chirukandath Gopinath, David H. Peters, David J. Lewis, Toshiaki Nishigaki, Yasunori Momose, Jun Naito. Toxicity Study of Bezafibrate (3). 1988; 22(13): 4337-4356
21. Shibata N, Yaguchi T, Akiyama K, Nishigaki T, Momose Y, Naito J. Toxicity Study of Bezafibrate (4). Clinical Report. 1988;22(13): 4357-4365 (Article in Japanese)
22. Watanabe T, Horie S, Yamada J, Suga T, Isaji M, Nishigaki T, Naito J. Species Differences of Bezafibrate in Liver Peroxisome. Clinical Report. 1988;22(13): 4367-4377 (Article in Japanese)
23. Momose Y, Nishigaki T, et al. Species Difference of Hypolipidemic Drug, Bezafibrate in Liver Peroxisome. Clinical Report. 1988;22(13):4379-4388 (Article in Japanese)
24. Isaji M, Miyasaka H, Isaka T, Nishigaki T, Momose Y, Naito J. Antigenicity Study of Bezafibrate in Guinea Pigs and Mice. Clinical Report. 1988;22(13): 4389-4400 (Article in Japanese)
25. Ooba M, Ozawa S, Nishigaki T, Naito J. Reproductive Study of Bezafibrate (1). Clinical Report. 1988; 22(13): 4401-4413 (Article in Japanese)
26. Naito J, Misawa T, Shibata N, Nishigaki T, Ozawa S, Ooba M. Reproductive Study of Bezafibrate (2). Clinical Report. 1988; 22(13): 4415-4432 (Article in Japanese)
27. Ooba M, Makita T, Misawa T, Ozawa S, Nishigaki T, Naito J. Reproductive Study of Bezafibrate (3). Clinical Report. 1988; 22(13): 4432-4452 (Article in Japanese)
28. Ooba M, Ozawa S, Nishigaki T, Naito J. Reproduction studies of bezafibrate. (1st report). Fertility study in rats. Clinical Report. 1988;22(13):4401-4413 (Article in Japanese)
29. Nishigaki T. Studies on the degranulation of mast cells (II): Radioautographic study of the localization of an anti-allergic agent, Tranilast, in mast cells. Jpn J Inflammation. 1988; 8(4): 341-345 (Article in Japanese)
30. Momose Y, Nishigaki T, et al. Species difference of peroxisome proliferation in hepatocytes by the hypolipidemic agent, bezafibrate. Quantitative microscopy comparison. Clinical Report. 1988;22(13):4379-4388 (Article in Japanese)
31. Nishigaki T, Shigematsu H, Tanaka M, Ishii Z, Kurata T. Unusual cystitis induced by anti-allergic drug, Tranilast. Surg pathol 1, 1988: 285-296Nishigaki
32. T, Shigematu H, Miyazaki K. Cystitis induced by anti-allergic drug,Tranilast: Histochemical study of mast cells. Medical J Shinshu University. 1988;36: 641-652 (Article in Japanese)
33. Nishigaki T¹, Momose Y, Nagata T. Light microscopic radioautographic study of the localization of an anti-allergic agent, Tranilast, in rat mast cells. Histochem J. 1987;19(10-11):533-6.
34. Nishigaki T, et al. Study on safety of OKY-046 Na. 1. Acute toxicity test in mice, rats and dogs. Clinical Report. 1986;20(5):2671-2679 (Article in Japanese)
35. Nagai H, Yamada H, Nishigaki T, Nakazawa M, Koda A. The susceptibility of experimental glomerulonephritis in six different strains of mice. J Pharmacobiodyn. 1985;8(7):586-9.
36. Nishigaki T, et al. Studies on safety of ritodrine hydrochloride. 8. Comparative studies on cardiotoxicity in rats by oral administration. Clinical Report. 1985;19(3):1334-1350 (Article in Japanese)
37. Momose Y, Nishigaki T, et al. Local toxicity test of ritodrine hydrochloride. Clinical Report. 1985;19(2):956-966 (Article in Japanese)
38. Kojima S, Tsutumi N, Momose Y, Nishigaki T, Ujiie A. Experimental Allergic Rhinitis in Rat and Effect of Tranilast. Medical J Shinshu University. 1983;31(2):123-127 (Article in Japanese)
39. Toshiaki Nishigaki, Hidekazu Shigematsu. Electron microscopical studies on degranulation of mast cells in type I allergic reaction. Jpn J Inflammation. 1982; 2 (4):339-340. (Article in Japanese)
40. Akagawa N, Kawahara N, Ito N, Nishigaki T, Kawai H. Schöenlein-Henoch syndrome associated with kidney disease. Nihon Rinsho. 1981; 39(7): 2683-5. (Article in Japanese)
41. Minamide M, Nishigaki T et al. Chronic Toxicity Study of N-(3,4-dimethoxycinnamoyl) anthranilic acid(N-5′) in Beagle dogs. Clinical Report.1980;14(7):1788-1874 (Article in Japanese)
42. Nishigaki T, et al. Effect of N-(3′,4′-dimethoxycinnamoyl) anthranilic acid (N-5′)in rat renal function, J Toxicological Science. 1977; 2(2):199-212 (Article in Japanese)
43. Eida K, Kubota N, Nishigaki T, Kikutani M.Harderian gland. V. Effect of dietary pantothenic acid deficiency on porphyrin biosynthesis in Harderian gland of rats. Chem Pharm Bull (Tokyo). 1975;23(1):1-4.

Books;
    1 Noni Scientific Booklet; Vol 1~4, Nishigaki T. Tokyo Noni Research Center (in Japanese, Korean)
    2 Noni Manga; Nishigaki T, Tokyo Noni Research Center. (in Japanese)
    3 Noni Mock Book. Edited by Nishigaki T., Forest publication (in Japanese)
   4 Buah Merah: Nishigaki T and Nakashima K., Ikuhousha (in Japanese)
   5 Buah Merah: Nishigaki T and I. S. Waspodo, CV. Cindy Printing  (in Bahasa Indonesia)